KMID : 1188320140080010029
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Gut and Liver 2014 Volume.8 No. 1 p.29 ~ p.34
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Ulcerative Colitis and Immunoglobulin G4
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Go Kuwata
Terumi Kamisawa Koichi Koizumi Taku Tabata Seiichi Hara Sawako Kuruma Takashi Fujiwara Kazuro Chiba Hideto Egashira Junko Fujiwara Takeo Arakawa Kumiko Momma Shinichiro Horiguchi
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Abstract
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Background/Aims:Ulcerative colitis (UC) is sometimes associated with autoimmune pancreatitis (AIP). Infiltration of immunoglobulin G4 (IgG4)-positive plasma cells is sometimes detected in the colonic mucosa of AIP or UC patients. This study aimed to clarify the relation between UC and IgG4.
Methods:Associations with UC were reviewed in 85 AIP patients. IgG4 immunostaining was performed on biopsy specimens from the colonic mucosa of 14 AIP and 32 UC patients.
Results:UC was confirmed in two cases (type 1 AIP, n=1; suspected type 2 AIP, n=1). Abundant infiltration of IgG4-positive plasma cells in the colonic mucosa was detected in the case of suspected type 2 AIP with UC and two cases of type 1 AIP without colitis. Abundant infiltration of IgG4-positive plasma cells was detected in 10 UC cases (IgG4-present, 31%). Although 72% of IgG4-absent UC patients showed mild disease activity, 70% of IgG4-present patients showed moderate to severe disease activity (p<0.05).
Conclusions:UC is sometimes associated with AIP, but it seems that UC is not a manifestation of IgG4-related disease. Infiltration of IgG4-positive plasma cells is sometimes detectable in the colonic mucosa of UC patients and is associated with disease activity.
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KEYWORD
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Colitis, ulcerative, Immunoglobulin G, Autoimmune pancreatitis
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